P21 activated kinases
نویسندگان
چکیده
منابع مشابه
Getting smart about p21-activated kinases.
p21-activated kinases (PAKs) are a family of Cdc42/Racactivated serine/threonine kinases involved in a variety of cellular processes, such as motility, migration, and cytoskeletal reorganization (1). Various members of the PAK family are known to influence brain development and cognitive function, but there remain many unanswered questions regarding PAK functions in neurons, the significance of...
متن کامل[P21-activated kinases and their role in the nervous system].
P21-activated kinases (PAK) participate in a variety of important cellular activities, such as cytoskeleton remodeling, cell migration, cell cycle regulation, and apoptosis or survival. PAK also has an important impact on brain development, neuronal differentiation, and regulation of synaptic plasticity in the nervous system. PAK abnormalities result in diseases including cancer, Parkinson's di...
متن کاملThe role of p21-activated kinases in hepatocellular carcinoma metastasis
The p21-activated kinases (PAKs) are downstream effectors of the Rho family small GTPases as well as a wide variety of mitogenic factors and have been implicated in cancer formation, development and metastasis. PAKs phosphorylate a wide spectrum of substrates to mediate extracellular signals and regulate cytoskeletal remodeling, cell motility and survival. In this review, we aim to summarize th...
متن کاملp21-activated kinases regulate actin remodeling in glomerular podocytes.
The tyrosine phosphorylation of nephrin is reported to regulate podocyte morphology via the Nck adaptor proteins. The Pak family of kinases are regulators of the actin cytoskeleton and are recruited to the plasma membrane via Nck. Here, we investigated the role of Pak in podocyte morphology. Pak1/2 were expressed in cultured podocytes. In mouse podocytes, Pak2 was predominantly phosphorylated, ...
متن کاملGlaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases.
Pancreatic cancer is one of the most lethal of human malignancies. Nearly 100% cases of pancreatic cancer carry mutations in KRas. P-21-activated kinases (PAKs) are activated by and act downstream of KRas. Glaucarubinone, a natural product first isolated from the seeds of the tree Simarouba glauca, was originally developed as an antimalarial drug, and has more recently been recognised as an ant...
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ژورنال
عنوان ژورنال: Small GTPases
سال: 2014
ISSN: 2154-1248,2154-1256
DOI: 10.4161/sgtp.28003